Simplifying Rifapentine Dosing for Tuberculosis Treatment and Prevention
نویسندگان
چکیده
منابع مشابه
Treatment of tuberculosis and optimal dosing schedules.
Intermittent tuberculosis treatment regimens have been developed to facilitate treatment supervision. Their efficacy has been substantiated by clinical trials and tuberculosis control programmes, notwithstanding the lack of head-to-head comparison between daily and intermittent regimens. Recently, there has been opposing evidence from observational studies, pharmacokinetic-pharmacodynamic studi...
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BACKGROUND Concomitant use of rifamycins to treat or prevent tuberculosis can result in subtherapeutic concentrations of antiretroviral drugs. We studied the interaction of efavirenz with daily rifapentine and isoniazid in human immunodeficiency virus (HIV)-infected individuals receiving a 4-week regimen to prevent tuberculosis. METHODS Participants receiving daily rifapentine and isoniazid w...
متن کاملDaily Dosing of Rifapentine Cures Tuberculosis in Three Months or Less in the Murine Model
BACKGROUND Availability of an ultra-short-course drug regimen capable of curing patients with tuberculosis in 2 to 3 mo would significantly improve global control efforts. Because immediate prospects for novel treatment-shortening drugs remain uncertain, we examined whether better use of existing drugs could shorten the duration of treatment. Rifapentine is a long-lived rifamycin derivative cur...
متن کاملThree months of rifapentine and isoniazid for latent tuberculosis infection.
BACKGROUND Treatment of latent Mycobacterium tuberculosis infection is an essential component of tuberculosis control and elimination. The current standard regimen of isoniazid for 9 months is efficacious but is limited by toxicity and low rates of treatment completion. METHODS We conducted an open-label, randomized noninferiority trial comparing 3 months of directly observed once-weekly ther...
متن کاملTuberculosis Prevention
بیماری سل بعنوان یک عفونت مزمن ، قابل درمان مهم در تسهیلات بهداشتی، مشکلات ناشی از پوشش و پیشگیری می باشد. طبق مدارک موجود، علیرغم واکسیناسیون است. هدف مهم بهداشت برای همه تا پیشرفتهائی که در این زمینه صورت گرفته، سل ریوی سال ۲۰۰۰، ایجاد پوشش وسیع واکسیناسیون برای یکی از مهمترین بیماریها از نظر میزان شیوع و منبع تمام دنیا می باشد. در سال ۱۹۹۰ واکسیناسیون عفونت در انسان می باشد.
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ژورنال
عنوان ژورنال: American Journal of Respiratory and Critical Care Medicine
سال: 2020
ISSN: 1073-449X,1535-4970
DOI: 10.1164/rccm.202006-2144ed